Archive: publications

  • Dr. Yi on the YAP Pathway

    Work from Dr Yi’s lab has recently demonstrated the important role of YAP pathway signaling down-stream of mutated ras in the progression of pancreatic cancer.

    Category: publications

  • Dr Toretsky and Colleagues on the Oncogenic fusion protein EWS-FLI1

    Dr Toretsky and colleagues have recently shown that EWS-FLI1, the fusion protein responsible for Ewing sarcoma, causes dramatic alterations in the mRNA splicing of many genes that have been implicated in oncogenesis. This study highlights altered RNA splicing as an important and understudied pro-oncogenic mechanism that differentiates tumor cells from normal cells and may provide opportunities for novel therapeutic strategies.

    Category: publications